Pub. Date : 2006 Nov 29
PMID : 17224080
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Spatio-temporal control of extracellular signal-regulated kinase (ERK) activity, a critical determinant of the cell"s response to growth factors, requires timely dephosphorylation of its regulatory tyrosine and/or threonine residue by MAPK phosphatases. | Tyrosine | mitogen-activated protein kinase 1 | Mus musculus |
| 2 | CONCLUSION: The finding that robust changes in tyrosine-specific MAPK phosphatase expression levels have minor effects on temporal ERK1/2 activity control in PC12 cells suggests that dual-specificity MAPK phosphatases may act as major regulators of growth factor-induced ERK1/2 signaling in these cells. | Tyrosine | mitogen-activated protein kinase 1 | Mus musculus |