Title : Dexamethasone damages the rat stomach but not small intestine during inhibition of COX-1.

Pub. Date : 2007 Jun

PMID : 17221297






2 Functional Relationships(s)
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1 In the animals treated with SC-560, iNOS expression was up-regulated in the intestinal but not the gastric mucosa, and this response was also inhibited by dexamethasone. Dexamethasone nitric oxide synthase 2 Rattus norvegicus
2 Dexamethasone does not provoke damage in the intestine, despite inhibiting the up-regulation of COX-2 expression under conditions of PG deficiency; at least one of the reasons is that this agent prevents the expression of iNOS, a major factor in the pathogenesis of intestinal lesions. Dexamethasone nitric oxide synthase 2 Rattus norvegicus