Pub. Date : 2007 Feb
PMID : 17200836
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | RESULTS: Quinine 3-hydroxylation was catalyzed to a similar extent by CYP3A4 and CYP3A5. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Quinine metabolism catalyzed by HLM, CYP3A4 and CYP3A5 was potently inhibited by the trans-enantiomer KTZ 2S,4S, with IC(50) value of 0.16 microM for HLM, 0.04 microM for CYP3A4 and 0.11 microM for CYP3A5. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Quinine metabolism catalyzed by HLM, CYP3A4 and CYP3A5 was potently inhibited by the trans-enantiomer KTZ 2S,4S, with IC(50) value of 0.16 microM for HLM, 0.04 microM for CYP3A4 and 0.11 microM for CYP3A5. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | CONCLUSIONS: Alprazolam and quinine metabolism is catalyzed by both CYP3A4 and CYP3A5. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |