Title : Role of a cysteine residue in the active site of ERK and the MAPKK family.

Pub. Date : 2007 Feb 16

PMID : 17194451






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The covalent bond motif in the ERK2/FR148083 complex assures that the inhibitor has high activity for ERK2 and no activity for other MAPKs such as JNK1 and p38MAPKalpha/beta/gamma/delta which have leucine residues at the site corresponding to Cys166 in ERK2. Leucine mitogen-activated protein kinase 1 Homo sapiens
2 The covalent bond motif in the ERK2/FR148083 complex assures that the inhibitor has high activity for ERK2 and no activity for other MAPKs such as JNK1 and p38MAPKalpha/beta/gamma/delta which have leucine residues at the site corresponding to Cys166 in ERK2. Leucine mitogen-activated protein kinase 1 Homo sapiens
3 The covalent bond motif in the ERK2/FR148083 complex assures that the inhibitor has high activity for ERK2 and no activity for other MAPKs such as JNK1 and p38MAPKalpha/beta/gamma/delta which have leucine residues at the site corresponding to Cys166 in ERK2. Leucine mitogen-activated protein kinase 1 Homo sapiens