Pub. Date : 2007 May 1
PMID : 17185461
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Different studies demonstrated that bortezomib breaks the chemoresistance in different tumor cells basically by altering nuclear factor-kappaB (NF-kappaB) activity. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Different studies demonstrated that bortezomib breaks the chemoresistance in different tumor cells basically by altering nuclear factor-kappaB (NF-kappaB) activity. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Whereas high-dose bortezomib induced direct cytotoxicity that correlated with decreased NF-kappaB activity, low-dose bortezomib sensitized HL cells against a variety of cytotoxic drugs without altering NF-kappaB action. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | The results identify XIAP as an NF-kappaB-independent target of bortezomib action that controls the chemoresistant phenotype of HL cells. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |