Title : Bcl-2 relieves deoxyadenylate stress and suppresses apoptosis in pre-B leukemia cells.

Pub. Date : 1995 Jan

PMID : 17180017






4 Functional Relationships(s)
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1 The influence of bcl-2 activity on 2"-deoxyadenosine-induced apoptosis was investigated in 697 human pre-B leukemia cells stably transfected with expression plasmid pHeBo-BCL-2alpha (697/BCL2 cells). 2'-deoxyadenosine BCL2 apoptosis regulator Homo sapiens
2 Bcl 2 overproduction also suppressed the accumulation of dAMP, dADP and dATP in cells exposed to 2"-deoxyadenosine in the presence of pentostatin to abrogate the pronounced inversion of ATP/dATP pools associated with 2"-deoxyadenosine exposure. 2'-deoxyadenosine BCL2 apoptosis regulator Homo sapiens
3 Bcl 2 overproduction also suppressed the accumulation of dAMP, dADP and dATP in cells exposed to 2"-deoxyadenosine in the presence of pentostatin to abrogate the pronounced inversion of ATP/dATP pools associated with 2"-deoxyadenosine exposure. 2'-deoxyadenosine BCL2 apoptosis regulator Homo sapiens
4 These results suggest that one consequence of bcl-2 activity is suppression of 2"-deoxyadenosine phosphorylation and elevation in the apoptotic target cells. 2'-deoxyadenosine BCL2 apoptosis regulator Homo sapiens