Title : Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor.

Pub. Date : 2006 Dec 1

PMID : 17145877






1 Functional Relationships(s)
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1 These results are consistent with the possibility that expression of Bcrp1 and P-glycoprotein at the apical side of the choroid plexus facilitates an influx transport mechanism across the blood-cerebrospinal fluid barrier, resulting in high topotecan CSF penetration. Topotecan ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus