Title : Dexamethasone inhibits paclitaxel-induced cytotoxic activity through retinoblastoma protein dephosphorylation in non-small cell lung cancer cells.

Pub. Date : 2007 Jan

PMID : 17143528






2 Functional Relationships(s)
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1 Pretreatment with 10 microM of dexamethasone inhibited ERK activation and subsequent retinoblastoma protein (pRB) phosphorylation, and reduced sensitivity to paclitaxel in A549 cells. Dexamethasone RB transcriptional corepressor 1 Homo sapiens
2 Our observation in this study raised the possibility that dexamethasone pretreatment antagonizes paclitaxel-induced cytotoxicity through ERK suppression and pRB dephosphorylation. Dexamethasone RB transcriptional corepressor 1 Homo sapiens