Title : Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt/beta-catenin signaling in HER2 overexpressing human breast cancer cells.

Pub. Date : 2007 Jan

PMID : 17143483






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 beta-catenin is a substrate of this kinase, and HER2-dependent phosphorylation of tyrosine 654 leads to dissociation of the E-cadherin-beta-catenin membrane complex and increased Wnt signaling. Tyrosine catenin beta 1 Homo sapiens
2 beta-catenin is a substrate of this kinase, and HER2-dependent phosphorylation of tyrosine 654 leads to dissociation of the E-cadherin-beta-catenin membrane complex and increased Wnt signaling. Tyrosine catenin beta 1 Homo sapiens