Pub. Date : 2007 Jan 19
PMID : 17141199
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenylarsine oxide inhibited beta-adrenergic receptor-mediated IL-6 secretion: inhibition of cAMP accumulation and CREB activation in cardiac fibroblasts. | oxophenylarsine | interleukin 6 | Mus musculus |
| 2 | To study the role of protein tyrosine phosphatases (PTPs) in beta-AR-mediated IL-6 production, we selected the most widely used PTP inhibitor, phenylarsine oxide (PAO). | oxophenylarsine | interleukin 6 | Mus musculus |
| 3 | To study the role of protein tyrosine phosphatases (PTPs) in beta-AR-mediated IL-6 production, we selected the most widely used PTP inhibitor, phenylarsine oxide (PAO). | oxophenylarsine | interleukin 6 | Mus musculus |
| 4 | We found that PAO dose-dependently inhibited the IL-6 release in response to beta-AR agonist isoproterenol (ISO) in mouse cardiac fibroblasts. | oxophenylarsine | interleukin 6 | Mus musculus |
| 5 | PAO also significantly inhibited the IL-6 production by forskolin, an adenylyl cyclase (AC) activator. | oxophenylarsine | interleukin 6 | Mus musculus |
| 6 | Furthermore, PAO dose-dependently inhibited the increased cAMP accumulation by either ISO or forskolin and suppressed the phosphorylation of CREB, an important transcriptional factor for IL-6 gene expression. | oxophenylarsine | interleukin 6 | Mus musculus |
| 7 | To our knowledge, this is the first report that PAO can inhibit ISO-induced IL-6 expression and CREB phosphorylation, demonstrating that PTPs may negatively regulate beta-AR-mediated IL-6 production. | oxophenylarsine | interleukin 6 | Mus musculus |
| 8 | To our knowledge, this is the first report that PAO can inhibit ISO-induced IL-6 expression and CREB phosphorylation, demonstrating that PTPs may negatively regulate beta-AR-mediated IL-6 production. | oxophenylarsine | interleukin 6 | Mus musculus |