Title : Cardiac metabolism and mechanics are altered by genetic loss of lipoprotein triglyceride lipolysis.

Pub. Date : 2006 Dec

PMID : 17139480






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Loss of cardiac LpL forces the heart to increase its uptake of glucose, reduce fatty acid oxidation, and eventually leads to cardiac dysfunction. Fatty Acids lipoprotein lipase Mus musculus
2 In contrast, cardiomyocyte specific overexpression of an anchored form of LpL leads to excess lipid uptake, induction of fatty acid oxidation genes, and dilated cardiomyopathy. Fatty Acids lipoprotein lipase Mus musculus