Pub. Date : 2006 Dec
PMID : 17139364
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease. | Disulfides | von Willebrand factor | Homo sapiens |
2 | Von Willebrand factor (VWF) contains a large number of cysteine residues, which all form disulfide bonds. | Disulfides | von Willebrand factor | Homo sapiens |
3 | Von Willebrand factor (VWF) contains a large number of cysteine residues, which all form disulfide bonds. | Disulfides | von Willebrand factor | Homo sapiens |
4 | Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. | Disulfides | von Willebrand factor | Homo sapiens |
5 | Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. | Disulfides | von Willebrand factor | Homo sapiens |
6 | Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. | Disulfides | von Willebrand factor | Homo sapiens |
7 | Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. | Disulfides | von Willebrand factor | Homo sapiens |
8 | Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. | Disulfides | von Willebrand factor | Homo sapiens |
9 | Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. | Disulfides | von Willebrand factor | Homo sapiens |