Title : Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease.

Pub. Date : 2006 Dec

PMID : 17139364






9 Functional Relationships(s)
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1 Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease. Disulfides von Willebrand factor Homo sapiens
2 Von Willebrand factor (VWF) contains a large number of cysteine residues, which all form disulfide bonds. Disulfides von Willebrand factor Homo sapiens
3 Von Willebrand factor (VWF) contains a large number of cysteine residues, which all form disulfide bonds. Disulfides von Willebrand factor Homo sapiens
4 Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. Disulfides von Willebrand factor Homo sapiens
5 Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. Disulfides von Willebrand factor Homo sapiens
6 Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. Disulfides von Willebrand factor Homo sapiens
7 Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. Disulfides von Willebrand factor Homo sapiens
8 Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. Disulfides von Willebrand factor Homo sapiens
9 Our data suggest that loss of a single disulfide bond in the CK-domain of VWF leads to a recessive, quantitative VWF deficiency if an intrachain-disulfide bond is involved, and to a dominant-negative, qualitative defect of VWF if an interchain-disulfide bond is involved. Disulfides von Willebrand factor Homo sapiens