Pub. Date : 2006 Oct-Dec
PMID : 17125596
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. | Polyamines | spermidine/spermine N1-acetyl transferase 1 | Mus musculus |
| 2 | The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. | Polyamines | spermidine/spermine N1-acetyl transferase 1 | Mus musculus |
| 3 | Contrary to SSAT deficient ES cells, polyamine pools in SSAT-KO mice remained almost unchanged in response to N(1),N(11)-diethylnorspermine (DENSPM) treatment compared to a significant reduction of the polyamine pools in the wild-type animals and ES cells. | Polyamines | spermidine/spermine N1-acetyl transferase 1 | Mus musculus |
| 4 | The latter finding indicates that inducible SSAT plays an essential role in vivo in DENSPM treatmentevoked polyamine depletion, but a controversial role in toxicity of DENSPM. | Polyamines | spermidine/spermine N1-acetyl transferase 1 | Mus musculus |
| 5 | Further characterization of SSAT knockout mice revealed insulin resistance at old age which supported the role of polyamine catabolism in glucose metabolism detected earlier with our SSAT overexpressing mice displaying enhanced basal metabolic rate, high insulin sensitivity and improved glucose tolerance. | Polyamines | spermidine/spermine N1-acetyl transferase 1 | Mus musculus |
| 6 | Further characterization of SSAT knockout mice revealed insulin resistance at old age which supported the role of polyamine catabolism in glucose metabolism detected earlier with our SSAT overexpressing mice displaying enhanced basal metabolic rate, high insulin sensitivity and improved glucose tolerance. | Polyamines | spermidine/spermine N1-acetyl transferase 1 | Mus musculus |