PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17125596-1 2006 The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. Polyamines 145-154 spermidine/spermine N1-acetyl transferase 1 Mus musculus 50-92 17125596-1 2006 The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. Polyamines 145-154 spermidine/spermine N1-acetyl transferase 1 Mus musculus 94-98 17125596-3 2006 Contrary to SSAT deficient ES cells, polyamine pools in SSAT-KO mice remained almost unchanged in response to N(1),N(11)-diethylnorspermine (DENSPM) treatment compared to a significant reduction of the polyamine pools in the wild-type animals and ES cells. Polyamines 37-46 spermidine/spermine N1-acetyl transferase 1 Mus musculus 56-60 17125596-5 2006 The latter finding indicates that inducible SSAT plays an essential role in vivo in DENSPM treatmentevoked polyamine depletion, but a controversial role in toxicity of DENSPM. Polyamines 107-116 spermidine/spermine N1-acetyl transferase 1 Mus musculus 44-48 17125596-7 2006 Further characterization of SSAT knockout mice revealed insulin resistance at old age which supported the role of polyamine catabolism in glucose metabolism detected earlier with our SSAT overexpressing mice displaying enhanced basal metabolic rate, high insulin sensitivity and improved glucose tolerance. Polyamines 114-123 spermidine/spermine N1-acetyl transferase 1 Mus musculus 28-32 17125596-7 2006 Further characterization of SSAT knockout mice revealed insulin resistance at old age which supported the role of polyamine catabolism in glucose metabolism detected earlier with our SSAT overexpressing mice displaying enhanced basal metabolic rate, high insulin sensitivity and improved glucose tolerance. Polyamines 114-123 spermidine/spermine N1-acetyl transferase 1 Mus musculus 183-187