Pub. Date : 1991 Jul 1
PMID : 1712101
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 2 | Western blot analysis reveals that PLC-gamma 1 is tyrosine-phosphorylated in response to TCR stimulation. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 3 | Thus, the TCR functions like PTK growth factor receptors, but through an indirect interaction, to induce tyrosine phosphorylation of PLC-gamma 1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 4 | Since other studies have implicated two members of the src family of PTKs in TCR-mediated signal transduction, our findings suggest that the induction of tyrosine phosphorylation of PLC-gamma 1 by a mechanism involving a src-like kinase may be the means by which the TCR regulates PLC activity in T cells. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |