Title : Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.

Pub. Date : 2007 May

PMID : 17119966






2 Functional Relationships(s)
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Protein Name
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1 NF-kappaB transfected MCF-7 and p53 knockout HCT116 cells were resistant to 5-FU (4.4- and 2.4-fold, respectively) but not to TDX. Fluorouracil nuclear factor kappa B subunit 1 Homo sapiens
2 Loss of p53 function and NF-kappaB over-expression may be involved in TS-independent 5-FU chemoresistance in some cancer cell lines. Fluorouracil nuclear factor kappa B subunit 1 Homo sapiens