Title : Interactions between endothelin-1 and other chronotropic agents in rat isolated atria.

Pub. Date : 1991 Mar 5

PMID : 1711980






2 Functional Relationships(s)
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1 The decrease may be partly dependent on the positive cronotropic and inotropic effects of endothelin-1, since other agents with chronotropic activity (noradrenaline, isoprenaline, serotonin and Bay k 8644) also decreased stimulation-induced chronotropic responses. Isoproterenol endothelin 1 Rattus norvegicus
2 Endothelin-1 caused a significant rightward shift of the linear portion of the log concentration-response curve for the chronotropic actions of noradrenaline and isoprenaline. Isoproterenol endothelin 1 Rattus norvegicus