Title : Cyclophane and acyclic cyclophane: novel channel blockers of N-methyl-D-aspartate receptor.

Pub. Date : 2007 Jan

PMID : 17113196






2 Functional Relationships(s)
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1 CPCn, CPPy, TGDMAP and ATGDMAP were found to inhibit macroscopic currents at heteromeric NMDA receptors (NR1/NR2), but not Ca(2+)-permeable AMPA receptors (GluR1), Ca(2+)-nonpermeable AMPA receptors (GluR1/GluR2) and metabotropic glutamate receptors (mGluR1alpha). TGDMAP glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 At a resting potential (-70 mV), the IC(50) values of CPCn, CPPy, TGDMAP and ATGDMAP for NR1/NR2A receptors were 0.5+/-0.1, 1.0+/-0.2, 8.0+/-0.8 and 4.9+/-0.5 microM, respectively. TGDMAP glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis