Pub. Date : 2006 Nov
PMID : 17112801
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In transactivation studies in CV-1 cells, we demonstrated that both CBZ and its major metabolite, CBZ-10,11-epoxide, activate the nuclear receptor PXR in a concentration-dependent fashion and at therapeutic concentrations with 50% inhibitory concentration values of approximately 50 micromol/L. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | CONCLUSIONS: CBZ is a potent inducer of a broad spectrum of drug-metabolizing enzymes and drug transporters in the human liver, and these effects are mediated at least in part by activation of PXR. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |