Title : MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling.

Pub. Date : 2007 Jan 26

PMID : 17107963






1 Functional Relationships(s)
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1 We found that growth factor-induced Ser-166 phosphorylation of Mdm2 was inhibited by the MEK inhibitors U0126 and PD98059 in HepG2 cells and in a rat liver cell line, TRL 1215. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one MDM2 proto-oncogene Homo sapiens