Title : Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety.

Pub. Date : 2006 Nov 23

PMID : 17107048






1 Functional Relationships(s)
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1 The quenching of this activated ester with a library of primary amines, followed by testing of the resulting amide library, led to the identification of organometallic Pim-1 and GSK-3 inhibitors with improved potencies and kinase selectivities. Amines Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens