Pub. Date : 2007 Feb
PMID : 17093202
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | However, recent studies in this laboratory showed that CYP2E1, and not esterase, is the primary enzyme responsible for urethane oxidation. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | Subsequent studies demonstrated significant inhibition of urethane-induced genotoxicity and cell proliferation in Cyp2e1-/- compared to Cyp2e1+/+ mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 4 | Subsequent studies demonstrated significant inhibition of urethane-induced genotoxicity and cell proliferation in Cyp2e1-/- compared to Cyp2e1+/+ mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 5 | Microscopic alterations included bronchoalveolar adenomas, and in one Cyp2e1+/+ mouse treated with 100 mg/kg urethane, a bronchoalveolar carcinoma was diagnosed. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 6 | In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 7 | In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 8 | In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 9 | In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |