PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17093202-0	2007	Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice.	Urethane	14-22	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	50-56	
17093202-3	2007	However, recent studies in this laboratory showed that CYP2E1, and not esterase, is the primary enzyme responsible for urethane oxidation.	Urethane	119-127	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	55-61	
17093202-4	2007	Subsequent studies demonstrated significant inhibition of urethane-induced genotoxicity and cell proliferation in Cyp2e1-/- compared to Cyp2e1+/+ mice.	Urethane	58-66	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	114-120	
17093202-4	2007	Subsequent studies demonstrated significant inhibition of urethane-induced genotoxicity and cell proliferation in Cyp2e1-/- compared to Cyp2e1+/+ mice.	Urethane	58-66	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	136-142	
17093202-10	2007	Microscopic alterations included bronchoalveolar adenomas, and in one Cyp2e1+/+ mouse treated with 100 mg/kg urethane, a bronchoalveolar carcinoma was diagnosed.	Urethane	109-117	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	70-76	
17093202-13	2007	In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity.	Urethane	65-73	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	101-107	
17093202-13	2007	In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity.	Urethane	65-73	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	123-129	
17093202-13	2007	In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity.	Urethane	65-73	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	154-160	
17093202-13	2007	In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity.	Urethane	207-215	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	154-160