Pub. Date : 2005 Dec
PMID : 17086498
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2). | 25-hydroxycholesterol | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | Pre-treatment of Caco-2 cells with 25-hydroxycholesterol significantly enhanced IL-1beta-induced IL-8 expression at both mRNA and protein levels. | 25-hydroxycholesterol | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Furthermore, pre-treatment with 25-hydroxycholesterol, followed by IL-1beta stimulation, enhanced IL-8 promoter activity beyond that observed with IL-1beta alone. | 25-hydroxycholesterol | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | These results suggest that 25-hydroxycholesterol enhances IL-1beta-induced IL-8 production, possibly by enhancing promoter activity. | 25-hydroxycholesterol | C-X-C motif chemokine ligand 8 | Homo sapiens |