PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17086498-0 2005 Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2). 25-hydroxycholesterol 19-40 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 17086498-5 2005 Pre-treatment of Caco-2 cells with 25-hydroxycholesterol significantly enhanced IL-1beta-induced IL-8 expression at both mRNA and protein levels. 25-hydroxycholesterol 35-56 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 17086498-7 2005 Furthermore, pre-treatment with 25-hydroxycholesterol, followed by IL-1beta stimulation, enhanced IL-8 promoter activity beyond that observed with IL-1beta alone. 25-hydroxycholesterol 32-53 C-X-C motif chemokine ligand 8 Homo sapiens 98-102 17086498-8 2005 These results suggest that 25-hydroxycholesterol enhances IL-1beta-induced IL-8 production, possibly by enhancing promoter activity. 25-hydroxycholesterol 27-48 C-X-C motif chemokine ligand 8 Homo sapiens 75-79