Title : Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.

Pub. Date : 2007 Apr

PMID : 17084978






2 Functional Relationships(s)
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1 To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. Catecholamines catechol-O-methyltransferase Rattus norvegicus
2 To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. Catecholamines catechol-O-methyltransferase Rattus norvegicus