Title : Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming.

Pub. Date : 2006 Nov 15

PMID : 17082775






1 Functional Relationships(s)
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1 Inhibition of the synthesis of putative trans imprinting factors with cycloheximide led to loss of IGF2 imprinting in normal cultured fibroblasts, suggesting that normal cells produce proteins that act in trans to induce or maintain genomic imprinting. Cycloheximide insulin like growth factor 2 Homo sapiens