Title : Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.

Pub. Date : 2006 Oct 24

PMID : 17055978






2 Functional Relationships(s)
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1 RESULTS: Characterization of cohesin"s ATPase activity suggests that hydrolysis depends on the binding of ATP to both Smc1 and Smc3 heads. Adenosine Triphosphate structural maintenance of chromosomes 3 Homo sapiens
2 We show that the C-terminal winged-helix domain of Scc1 stimulates the ATPase activity of the Smc1/Smc3 heterodimer by promoting ATP binding to Smc1"s head. Adenosine Triphosphate structural maintenance of chromosomes 3 Homo sapiens