Title : TLR4 links innate immunity and fatty acid-induced insulin resistance.

Pub. Date : 2006 Nov

PMID : 17053832






4 Functional Relationships(s)
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1 TLR4 links innate immunity and fatty acid-induced insulin resistance. Fatty Acids toll-like receptor 4 Mus musculus
2 Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4. Fatty Acids toll-like receptor 4 Mus musculus
3 Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4. Fatty Acids toll-like receptor 4 Mus musculus
4 Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4. Fatty Acids toll-like receptor 4 Mus musculus