Title : Preferential accumulation of Abeta(1-42) on gel phase domains of lipid bilayers: an AFM and fluorescence study.

Pub. Date : 2007 Jan

PMID : 17052685






2 Functional Relationships(s)
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1 As a model, we have examined the interaction of Abeta(1-42) with phase separated DOPC/DPPC lipid bilayers using a combination of atomic force microscopy (AFM) and total internal reflection fluorescence microscopy (TIRF). 1,2-Dipalmitoylphosphatidylcholine amyloid beta precursor protein Homo sapiens
2 AFM images show that addition of Abeta to preformed supported bilayers leads to accumulation of small peptide aggregates exclusively on the gel phase DPPC domains. 1,2-Dipalmitoylphosphatidylcholine amyloid beta precursor protein Homo sapiens