Pub. Date : 1991 Feb 1
PMID : 1704355
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated whether EGF could be conjugated to dextran, which is a suitable carrier for toxic agents, without losing its ability to bind to the receptor. | Dextrans | epidermal growth factor | Homo sapiens |
| 2 | EGF was coupled to the activated dextran through the amino terminus and glycine was added to block residual activity. | Dextrans | epidermal growth factor | Homo sapiens |
| 3 | The EGF-dextran conjugate was, after purification on Sephadex G25 and Sephacryl 200 columns, tested for its receptor binding properties on human malignant glioma, U343MGaC12:6, cells. | Dextrans | epidermal growth factor | Homo sapiens |
| 4 | Thus, it seems promising to use dextran, conjugated with EGF, as a carrier of, for example, toxic radioactive nuclides. | Dextrans | epidermal growth factor | Homo sapiens |