Title : Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

Pub. Date : 2007 Jan

PMID : 17041008






1 Functional Relationships(s)
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1 In contrast, carbamazepine (CMZ), efavirenz (EFV), and nevirapine (NVP) were classified as negligible or weak hPXR activators at concentrations associated with efficacious CYP2B6 reporter or endogenous gene induction in primary human hepatocytes, suggesting potential activation of hCAR. Carbamazepine nuclear receptor subfamily 1 group I member 2 Homo sapiens