Pub. Date : 2007 Apr
PMID : 17039513
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Platelet GPIIb/IIIa antagonist, XV459, in heparin-induced thrombocytopenia. | Heparin | integrin subunit alpha 2b | Homo sapiens |
| 2 | In this study, the ability of a novel platelet GPIIb/IIIa antagonist, a free acid form of roxifiban (XV459), to block platelet activation/aggregation in response to highly characterized heparin-PF4 antibody-positive plasma/heparin was examined using light transmittance aggregometry, serotonin release, and (125)I-fibrinogen binding assays to human platelets. | Heparin | integrin subunit alpha 2b | Homo sapiens |
| 3 | The platelet GPIIb/IIIa receptor antagonist (XV459) might be of potential benefit in the management of thrombotic thrombocytopenia produced by heparin and/or related glycosaminoglycans. | Heparin | integrin subunit alpha 2b | Homo sapiens |