Pub. Date : 2007 Jan 1
PMID : 17035026
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. | Pyrrolidonecarboxylic Acid | thyrotropin releasing hormone | Homo sapiens |
| 2 | Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. | Pyrrolidonecarboxylic Acid | thyrotropin releasing hormone | Homo sapiens |
| 3 | Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. | Pyrrolidonecarboxylic Acid | thyrotropin releasing hormone | Homo sapiens |
| 4 | For example, the most selective agonist of the series 13, in which pGlu is replaced with the pAad and histidine residue is substituted at the N-1 position with an isopropyl group, was found to activate TRH-R2 with a potency (EC(50)=1.9microM) but did not activate TRH-R1 (potency>100 microM); that is, exhibited >51-fold greater selectivity for TRH-R2 versus TRH-R1. | Pyrrolidonecarboxylic Acid | thyrotropin releasing hormone | Homo sapiens |