Pub. Date : 1991 Jan 29
PMID : 1703436
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional interaction of plasminogen activator inhibitor type 1 (PAI-1) and heparin. | Heparin | serpin family E member 1 | Homo sapiens |
| 2 | Recently, it has been demonstrated that the PAI-1-binding site on vitronectin is adjacent to a heparin-binding site (Preissner et al., 1990). | Heparin | serpin family E member 1 | Homo sapiens |
| 3 | Furthermore, it can be deduced that the amino acid residues, proposed to mediate heparin binding in the serpins antithrombin III and heparin cofactor II, are conserved in PAI-1. | Heparin | serpin family E member 1 | Homo sapiens |
| 4 | At pH 7.4, PAI-1 quantitatively binds to heparin-Sepharose and can be eluted with increasing [NaCl]. | Heparin | serpin family E member 1 | Homo sapiens |
| 5 | Binding of PAI-1 to heparin-Sepharose can be efficiently competed with heparin in solution (IC50, 7 microM). | Heparin | serpin family E member 1 | Homo sapiens |
| 6 | Binding of PAI-1 to heparin-Sepharose can be efficiently competed with heparin in solution (IC50, 7 microM). | Heparin | serpin family E member 1 | Homo sapiens |
| 7 | In the presence of heparin, the protease specificity of PAI-1 toward thrombin is substantially increased. | Heparin | serpin family E member 1 | Homo sapiens |
| 8 | This is shown by (i) quenching of thrombin activity of PAI-1 in the presence of heparin and (ii) induction of the formation of SDS-stable complexes between thrombin and PAI-1 by heparin. | Heparin | serpin family E member 1 | Homo sapiens |
| 9 | This is shown by (i) quenching of thrombin activity of PAI-1 in the presence of heparin and (ii) induction of the formation of SDS-stable complexes between thrombin and PAI-1 by heparin. | Heparin | serpin family E member 1 | Homo sapiens |
| 10 | This is shown by (i) quenching of thrombin activity of PAI-1 in the presence of heparin and (ii) induction of the formation of SDS-stable complexes between thrombin and PAI-1 by heparin. | Heparin | serpin family E member 1 | Homo sapiens |
| 11 | This is shown by (i) quenching of thrombin activity of PAI-1 in the presence of heparin and (ii) induction of the formation of SDS-stable complexes between thrombin and PAI-1 by heparin. | Heparin | serpin family E member 1 | Homo sapiens |