Title : The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs.

Pub. Date : 2007 Jan

PMID : 17031514






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1 We evaluated growth-inhibitory activity of flavanone and 2"-OH flavanone against highly proliferative human lung cancer cells (A549) via anchorage-independent and -dependent colony formation assay, and further showed that treatment of flavanone resulted in a G1 cell cycle arrest with reduction of cyclin D, E and cyclin-dependent kinase (CDK) 2, while treatment of 2"-OH flavanone led to a G2/M phase accumulation with reduction of cyclin B, D and Cdc2. flavanone cyclin dependent kinase 1 Homo sapiens