Pub. Date : 2006 Nov
PMID : 17026490
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells. | Nelfinavir | insulin | Homo sapiens |
| 2 | The ability of insulin to inhibit the proteasome was abrogated by nelfinavir. | Nelfinavir | insulin | Homo sapiens |
| 3 | Addition of 50 microm nelfinavir inhibited cellular protein degradation by 14% and blunted the effect of insulin. | Nelfinavir | insulin | Homo sapiens |
| 4 | These data show that nelfinavir inhibits IDE, decreases insulin"s ability to inhibit protein degradation via the proteasome and provides another possible mechanism for the insulin resistance seen in protease inhibitor-treated HIV patients. | Nelfinavir | insulin | Homo sapiens |
| 5 | These data show that nelfinavir inhibits IDE, decreases insulin"s ability to inhibit protein degradation via the proteasome and provides another possible mechanism for the insulin resistance seen in protease inhibitor-treated HIV patients. | Nelfinavir | insulin | Homo sapiens |