Title : Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines.

Pub. Date : 2006 Nov

PMID : 17016659






3 Functional Relationships(s)
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1 In this study, we investigated the molecular mechanisms of apoptosis induction in hepatoma cell lines with IFNalpha and 5-FU combination therapy from the view point of 5-FU"s additive effect on interferon-related signaling pathways. Fluorouracil interferon alpha 1 Homo sapiens
2 In this study, we investigated the molecular mechanisms of apoptosis induction in hepatoma cell lines with IFNalpha and 5-FU combination therapy from the view point of 5-FU"s additive effect on interferon-related signaling pathways. Fluorouracil interferon alpha 1 Homo sapiens
3 The JAK/STAT pathway transcriptional factor ISRE was activated more synergistically when 5-FU was added to IFNalpha treatments. Fluorouracil interferon alpha 1 Homo sapiens