Title : Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.

Pub. Date : 2007

PMID : 17015027






3 Functional Relationships(s)
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1 Nicotinic acetylcholine receptors (nAChR) are expressed on non-neuronal cell types, including normal bronchial epithelial cells, and nicotine has been reported to cause Akt activation in cultured normal airway cells. Nicotine AKT serine/threonine kinase 1 Homo sapiens
2 Akt was also phosphorylated in NSCLC cells after exposure to nicotine; this effect was inhibited by the PI3K inhibitor LY294002 and antagonists to the neuronal-type nAChR, but not to the muscle-type receptor. Nicotine AKT serine/threonine kinase 1 Homo sapiens
3 273T cells also showed greater activation of p44/42 MAPK than of Akt in response to nicotine. Nicotine AKT serine/threonine kinase 1 Homo sapiens