Title : Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene?

Pub. Date : 2006 Nov

PMID : 17009149






3 Functional Relationships(s)
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1 Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene? Folfox protocol X-ray repair cross complementing 1 Homo sapiens
2 Response to FOLFOX was better in the patient group with mutations for MTHFR and worse in the patient group with mutations for XRCC1. Folfox protocol X-ray repair cross complementing 1 Homo sapiens
3 However, only the XRCC1 polymorphism was a significant prognostic factor for the response to FOLFOX chemotherapy and short-term survival. Folfox protocol X-ray repair cross complementing 1 Homo sapiens