Title : Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.

Pub. Date : 2006 Nov 24

PMID : 17005562






2 Functional Relationships(s)
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1 CENTB1 expression in epithelial cells was highly induced by tumor necrosis factor alpha, interleukin 1beta, and the NOD1 and NOD2 ligands (gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively). N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid nucleotide binding oligomerization domain containing 2 Homo sapiens
2 Functionally, CENTB1 overexpression inhibited NOD1- and NOD2-dependent activation of NF-kappaB, whereas small inhibitory RNA against CENTB1 increased NF-kappaB activation following NOD1- or NOD2-mediated recognition of the bacterial components gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively. N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid nucleotide binding oligomerization domain containing 2 Homo sapiens