Protein Name nucleotide binding oligomerization domain containing 2
Organism Homo sapiens
Gene ID 64127
Gene Symbol


UniProt Q9HC29 (NOD2_HUMAN), A0A286YF65 (A0A286YF65_HUMAN)
Relationships Total Number of functionally related compound(s) : 234
Total Number of Articles : 361

nucleotide binding oligomerization domain containing 2

Gene Summary

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

  • nucleotide-binding oligomerization domain-containing protein 2
  • NLR family, CARD domain containing 2
  • NOD-like receptor C2
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