Pub. Date : 1990 Sep 15
PMID : 1700499
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of cytochrome P(1)450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthracene. | benz(a)anthracene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | We have examined the steady-state level of RNA from the P(1)450 gene and the metabolism of benzo[a]pyrene (BP) in primary cultures of human hepatocytes exposed for up to 4 days to 12.5 microM benzanthracene (BA), and in uninduced control cultures. | benz(a)anthracene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | While the steady-state levels of RNA from the P(1)450 gene were nondetectable in uninduced (DMSO only) human hepatocytes, 12.5 microM BA-induced AHH activity, BP metabolism, and/or P(1)450-specific RNA in hepatocytes from seven human cases were investigated. | benz(a)anthracene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | While the steady-state levels of RNA from the P(1)450 gene were nondetectable in uninduced (DMSO only) human hepatocytes, 12.5 microM BA-induced AHH activity, BP metabolism, and/or P(1)450-specific RNA in hepatocytes from seven human cases were investigated. | benz(a)anthracene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Exposure of human hepatocytes in vitro to BA leads to a large increase in the steady-state level of the RNA specific for the P(1)450 gene and an increase metabolism of BP. | benz(a)anthracene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |