Pub. Date : 2007 Mar
PMID : 17003101
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this connection, the ERK1/2 inhibitor U0126 abrogated the upregulation of AP-1 and COX-2 as well as cell proliferation induced by nicotine. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Inhibition of PKC by staurosporine attenuated nicotine-induced ERK1/2 phosphorylation and COX-2 expression. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Furthermore, atenolol and ICI 118,551, a beta1- and beta2-adrenoceptor antagonist, respectively, reversed the stimulatory action of nicotine on the expression of PKC, ERK1/2 phosphorylation, and COX-2 together with cell proliferation. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Collectively, these results suggest that nicotine stimulates gastric cancer cell growth through the activation of beta-adrenoceptors and the downstream PKC-betaI/ERK1/2/COX-2 pathway. | Nicotine | mitogen-activated protein kinase 3 | Homo sapiens |