Pub. Date : 2006 Nov
PMID : 17001711
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In the completion of our fluorine scan of tricyclic inhibitors to map the fluorophilicity/fluorophobicity of the thrombin active site, a series of 11 new ligands featuring alkyl, alkenyl, and fluoroalkyl groups was prepared to explore fluorine effects on binding into the hydrophobic proximal (P) pocket, lined by Tyr 60A and Trp 60D, His 57, and Leu 99. | Histidine | coagulation factor II, thrombin | Homo sapiens |