Title : ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.

Pub. Date : 2006 Dec

PMID : 16995874






3 Functional Relationships(s)
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1 ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK. vandetanib mechanistic target of rapamycin kinase Homo sapiens
2 ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK. vandetanib mechanistic target of rapamycin kinase Homo sapiens
3 Interestingly, when ZD6474 was combined with sunitinib (SU11248; Sutent, Pfizer, Kalamazoo, MI, USA), a class III and V receptor tyrosine kinase inhibitor, the ZD6474-mediated growth inhibition was potentiated in association with further down-regulation of the mTOR targets p-p70S6K and p-4E-BP-1. vandetanib mechanistic target of rapamycin kinase Homo sapiens