Title : Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands.

Pub. Date : 2006 Dec

PMID : 16985168






1 Functional Relationships(s)
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1 CYP2C18, 2C19, 2C9, 2W1, 3A4, and 4B1 are up-regulated by cellular differentiation; mRNA levels for these CYP genes were inhibited in differentiating keratinocytes exposed to retinoic acid and aryl hydrocarbon receptor (AhR) ligands. Tretinoin cytochrome P450 family 2 subfamily C member 18 Homo sapiens