Pub. Date : 2006 Nov 15
PMID : 16984800
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Importantly, celastrol inhibited IKK activity and the constitutively active IKK beta activity in a dose-dependent manner without either affecting the NF-kappa B activation induced by RelA over-expression or directly suppressing the DNA-binding of activated NF-kappa B. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | However, mutation of cysteine 179 in the activation loop of IKK beta abolished sensitivity towards to celastrol, suggesting that celastrol suppressed the NF-kappa B activation by targeting cysteine 179 in the IKK. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | To verify that celastrol is a NF-kappa B inhibitor, we investigated its effect on some NF-kappa B target genes expressions. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | To verify that celastrol is a NF-kappa B inhibitor, we investigated its effect on some NF-kappa B target genes expressions. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Taken together, this study extends our understanding on the molecular mechanisms underlying the anti-inflammatory and anti-cancer activities of celastrol and celastrol-containing medicinal plant, which would be a valuable candidate for the intervention of NF-kappa B-dependent pathological conditions. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Taken together, this study extends our understanding on the molecular mechanisms underlying the anti-inflammatory and anti-cancer activities of celastrol and celastrol-containing medicinal plant, which would be a valuable candidate for the intervention of NF-kappa B-dependent pathological conditions. | celastrol | nuclear factor kappa B subunit 1 | Homo sapiens |