Title : Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin.

Pub. Date : 2006 Nov

PMID : 16978829






3 Functional Relationships(s)
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1 Using enzyme-linked immunosorbent assays (ELISAs) we showed DHMEQ to inhibit LPS-induced secretion of IL-6, IL-12, interleukin-1beta (IL-1beta), and TNF-alpha. dehydroxymethylepoxyquinomicin interleukin 1 beta Mus musculus
2 Using enzyme-linked immunosorbent assays (ELISAs) we showed DHMEQ to inhibit LPS-induced secretion of IL-6, IL-12, interleukin-1beta (IL-1beta), and TNF-alpha. dehydroxymethylepoxyquinomicin interleukin 1 beta Mus musculus
3 Furthermore, DHMEQ also inhibited the phagocytosis of fluorescently labeled Escherichia coli by RAW264.7 cells treated with LPS or IL-1beta, thus being the first evidence for the involvement of NF-kappaB in the regulation of phagocytosis by use of this inhibitor. dehydroxymethylepoxyquinomicin interleukin 1 beta Mus musculus