Title : Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells.

Pub. Date : 2006 Oct

PMID : 16969513






2 Functional Relationships(s)
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1 Furthermore, we observed that paclitaxel, ceramide, or combo-induced EGFR phosphorylation was inhibited by EGFR inhibitor, PD153035, while paclitaxel, ceramide, or combo-induced JNK and ERK phosphorylation was blocked by EGFR inhibitor, PD153035 and ERK inhibitor, U126. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline mitogen-activated protein kinase 1 Homo sapiens
2 Furthermore, we observed that paclitaxel, ceramide, or combo-induced EGFR phosphorylation was inhibited by EGFR inhibitor, PD153035, while paclitaxel, ceramide, or combo-induced JNK and ERK phosphorylation was blocked by EGFR inhibitor, PD153035 and ERK inhibitor, U126. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline mitogen-activated protein kinase 1 Homo sapiens